Table 4.
Genome‐Wide Complex Trait Analysis (GCTA) of the 7 Phenotypes Investigated
| Phenotype | Source | Variance | SE | P Value |
|---|---|---|---|---|
| Cystatin C | V genotypic (g) | 0.404 | 0.0763 | |
| V environmental (e) | 0.608 | 0.0749 | ||
| V phenotypic (p) | 1.012 | 0.0192 | ||
| V (g)/V (p)* | 0.399 | 0.0743 | 8E−9 | |
| Creatinine | V genotypic (g) | 0.190 | 0.0727 | |
| V environmental (e) | 0.798 | 0.0733 | ||
| V phenotypic (p) | 0.988 | 0.0186 | ||
| V (g)/V (p) | 0.192 | 0.0733 | 0.003 | |
| eGFR (Cystatin C)* | V genotypic (g) | 0.418 | 0.0766 | |
| V environmental (e) | 0.594 | 0.0751 | ||
| V phenotypic (p) | 1.012 | 0.0192 | ||
| V (g)/V (p) | 0.413 | 0.0644 | 3E−9 | |
| MDRD (Creatinine)* | V genotypic (g) | 0.186 | 0.0720 | |
| V environmental (e) | 0.791 | 0.0726 | ||
| V phenotypic (p) | 0.977 | 0.0184 | ||
| V (g)/V (p) | 0.191 | 0.0734 | 0.004 | |
| Cdk‐epi (Cystatin C+Creatinine)* | V genotypic (g) | 0.192 | 0.0737 | |
| V environmental (e) | 0.821 | 0.0744 | ||
| V phenotypic (p) | 1.013 | 0.0191 | ||
| V (g)/V (p) | 0.190 | 0.0725 | 0.003 | |
| Cdk‐epi (Cystatin C)* | V genotypic (g) | 0.247 | 0.0733 | |
| V environmental (e) | 0.769 | 0.0735 | ||
| V phenotypic (p) | 1.016 | 0.0192 | ||
| V (g)/V (p) | 0.243 | 0.0717 | 9E−5 | |
| Cdk‐epi (Creatinine)* | V genotypic (g) | 0.084 | 0.0707 | |
| V environmental (e) | 0.918 | 0.0724 | ||
| V phenotypic (p) | 1.002 | 0.0189 | ||
| V (g)/V (p) | 0.084 | 0.0705 | 0.1 |
All values adjusted for age, sex and correlated principal components. eGFR indicates estimated glomerular filtration rate; MDRD, Modification of Diet in Renal Disease; SE, standard error; V, variance.
*
V(g)/V(p)=h2 (heritability).
*
Glomerular filtration rate (GFR) according to the modification of diet in renal disease (MDRD)‐formula.
*
Machine calculated GFR.
*
GFR according to the CKD‐epi formula.