. 2015 Jan 9;4(1):e001521. doi: 10.1161/JAHA.114.001521

Table 7.

Replication Analysis of the Best GENRES Losartan 24‐H Ambulatory Blood Pressure Response SNPs With Office Blood Pressure Responses to Candesartan in GERA II and to Losartan in SOPHIA

Rank in GENRES	SNP	Chr	Position (Build 37)	Replication Results From GERA II (N=198)							Replication Results From SOPHIA (N=372)
Rank in GENRES	SNP	Chr	Position (Build 37)	CA/NCA	CAF	r² imp.	SBP/DBP	β	P Value	Direction of Replication	CA/NCA	CAF	r² imp.	SBP/DBP	β	P Value	Direction of Replication
1	rs1370555	15	97 049 985	C/T	0.51	1.00	SBP	−0.3	0.84	Same	T/C	0.42	—	SBP	0.2	0.76	Same
1							DBP	0.2	0.82	Opposite				DBP	0.2	0.60	Same
2	rs7086428	10	130 778 452	A/G	0.35	—	SBP	−1.6	0.22	Opposite	A/G	0.36	—	SBP	0.7	0.26	Same
2							DBP	−0.6	0.55	Opposite				DBP	0.1	0.74	Same
3	rs4953045	2	44 268 800	C/T	0.24	0.90	SBP	−1.9	0.25	Same	C/T	0.28	—	SBP	−1.3	0.06	Same
3							DBP	−2.1	0.10	Same				DBP	0.2	0.77	Opposite
4	rs711513	7	109 368 769	A/G	0.70	0.98	SBP	−0.2	0.91	Opposite	G/A	0.39	—	SBP	−0.7	0.29	Same
4							DBP	−0.7	0.51	Opposite				DBP	−0.3	0.49	Same
5	rs12814605	12	63 438 145	C/T	0.87	0.99	SBP	−0.8	0.69	Opposite	T/C	0.13	—	SBP	−1.0	0.29	Same
5							DBP	0.7	0.62	Same				DBP	−1.0	0.14	Same
6	rs2279989	9	1 041 524	A/G	0.06	0.98	SBP	3.0	0.32	Opposite	A/G	0.06	—	SBP	1.3	0.34	Opposite
6							DBP	1.6	0.47	Opposite				DBP	0.1	0.93	Opposite
7	rs7597606	2	41 836 313	C/T	0.58	0.96	SBP	−0.6	0.65	Same	T/C	0.42	—	SBP	0.1	0.86	Same
7							DBP	−0.8	0.43	Same				DBP	0.2	0.72	Same
8	rs1559557	2	57 332 673	C/T	0.38	0.99	SBP	0.1	0.92	Same	C/T	0.37	—	SBP	−0.6	0.34	Opposite
8							DBP	−0.3	0.77	Opposite				DBP	−0.7	0.15	Opposite
9	rs1432232	2	137 799 664	G/T	0.71	—	SBP	2.8	0.06	Opposite	T/G	0.26	—	SBP	−0.3	0.64	Opposite
9							DBP	1.8	0.11	Opposite				DBP	−0.6	0.27	Opposite
10	rs1993802	3	110 595 402	C/T	0.08	—	SBP	1.4	0.60	Opposite	C/T	0.10	—	SBP	0.3	0.75	Opposite
10							DBP	1.4	0.48	Opposite				DBP	−0.5	0.46	Same
11	rs12602832	17	42 396 896	NA							T/C	0.06	—	SBP	−0.6	0.67	Same
11														DBP	−0.5	0.57	Same
12	rs2038912	10	20 207 349	C/T	0.42	1.00	SBP	1.5	0.26	Opposite	C/T	0.42	—	SBP	−0.8	0.22	Same
12							DBP	0.8	0.41	Opposite				DBP	−0.4	0.45	Same
13	rs4759885	12	131 736 813	C/T	0.58	0.99	SBP	1.6	0.20	Opposite	T/C	0.34	—	SBP	−0.4	0.48	Opposite
13							DBP	1.0	0.31	Opposite				DBP	−0.6	0.21	Opposite
14	rs771574	3	101 620 682	A/G	0.63	1.00	SBP	−0.3	0.84	Opposite	G/A	0.27	—	SBP	0.5	0.51	Opposite
14							DBP	−0.0	0.99	Opposite				DBP	0.4	0.40	Opposite
15	rs10754459	1	245 785 508	NA							C/T	0.22	—	SBP	1.2	0.14	Opposite
15														DBP	0.9	0.12	Opposite
16	rs1392874	4	101 466 820	A/C	0.43	0.99	SBP	−1.1	0.43	Same	A/C	0.39	—	SBP	0.6	0.38	Opposite
16							DBP	−0.4	0.71	Same				DBP	0.0	0.97	Opposite
17	rs1357365	17	34 436 532	A/G	0.30	1.00	SBP	−0.3	0.84	Opposite	A/G	0.35	—	SBP	0.2	0.81	Same
17							DBP	0.1	0.95	Same				DBP	0.4	0.44	Same
18	rs3814995	19	36 342 212	C/T	0.68	0.19	SBP	7.1	0.03	Same	T/C	0.28	—	SBP	−0.9	0.19	Same
18							DBP	5.9	0.02	Same				DBP	−1.1	0.03	Same
19	rs11841583	13	31 495 179	A/G	0.13	0.83	SBP	0.6	0.78	Opposite	A/G	0.05	—	SBP	2.6	0.07	Opposite
19							DBP	0.7	0.67	Opposite				DBP	0.8	0.43	Opposite
20	rs17271855	19	5 524 721	C/T	0.83	0.88	SBP	−2.2	0.23	Opposite	T/C	0.20	—	SBP	−0.0	0.99	Same
20							DBP	−0.5	0.72	Opposite				DBP	−0.1	0.81	Same

The loci are listed in the order of their rank in GENRES. CA indicates coded allele; CAF, coded allele frequency; Chr, chromosome; DBP, diastolic blood pressure; NA, not analyzed; NCA, noncoded allele; r² imp, r² values for imputed SNPs; SBP, systolic blood pressure; SNP, single‐nucleotide polymorphism.