Table 8.
Replication Analysis of the Best GENRES Bisoprolol 24‐H Ambulatory Blood Pressure Response SNPs With Ambulatory 24‐H Blood Pressure Responses to Atenolol in PEAR
| Rank in GENRES | SNP | Chr | Position (Build 37) | Replication Results From PEAR (N=192 to 193) | |||||
|---|---|---|---|---|---|---|---|---|---|
| CA/NCA | CAF | SBP/DBP | β | P Value | Direction of Replication | ||||
| 1 | rs2514036 | 11 | 67 415 054 | C/T | 0.18 | SBP | 0.7 | 0.58 | Opposite |
| DBP | 0.5 | 0.56 | Opposite | ||||||
| 2 | rs7268800 | 20 | 38 580 738 | G/A | 0.37 | SBP | −0.5 | 0.61 | Same |
| DBP | −0.9 | 0.14 | Same | ||||||
| 3 | rs12967284 | 18 | 12 532 098 | T/C | 0.34 | SBP | 0.1 | 0.90 | Same |
| DBP | 0.2 | 0.75 | Same | ||||||
| 4 | rs4357510 | 1 | 192 612 394 | A/C | 0.06 | SBP | 1.5 | 0.37 | Opposite |
| DBP | 1.0 | 0.35 | Opposite | ||||||
| 5 | rs2506143 | 10 | 33 468 169 | G/A | 0.17 | SBP | 1.3 | 0.28 | Same |
| DBP | 0.9 | 0.26 | Same | ||||||
| 6 | rs2029870 | 6 | 164 888 366 | A/G | 0.21 | SBP | −0.6 | 0.61 | Same |
| DBP | 0.2 | 0.84 | Opposite | ||||||
| 7 | rs7984003 | 13 | 82 866 573 | T/C | 0.18 | SBP | 2.1 | 0.07 | Same |
| DBP | 0.5 | 0.52 | Same | ||||||
| 8 | rs11777699 | 8 | 6 714 699 | G/A | 0.45 | SBP | −0.0 | 0.99 | Same |
| DBP | 0.2 | 0.75 | Opposite | ||||||
| 9 | rs10519585 | 5 | 118 676 529 | C/T | 0.35 | SBP | −0.2 | 0.79 | Same |
| DBP | 0.3 | 0.63 | Opposite | ||||||
| 10 | rs6501061 | 16 | 8 092 171 | C/T | 0.04 | SBP | 1.4 | 0.55 | Same |
| DBP | 0.7 | 0.65 | Same | ||||||
| 11 | rs16918900 | 8 | 54 147 242 | T/C | 0.04 | SBP | 0.1 | 0.97 | Opposite |
| DBP | 0.6 | 0.67 | Opposite | ||||||
| 12 | rs2194860 | 4 | 109 948 511 | A/G | 0.16 | SBP | 0.2 | 0.87 | Same |
| DBP | −0.3 | 0.72 | Opposite | ||||||
| 13 | rs2765115 | 13 | 24 529 399 | G/A | 0.13 | SBP | −2.2 | 0.14 | Same |
| DBP | −0.4 | 0.71 | Same | ||||||
| 14 | rs17642669 | 5 | 140 628 277 | G/A | 0.05 | SBP | −1.5 | 0.48 | Same |
| DBP | 0.4 | 0.80 | Opposite | ||||||
| 15 | rs7895038 | 10 | 2 432 266 | T/C | 0.47 | SBP | 0.0 | 0.98 | Opposite |
| DBP | 0.3 | 0.60 | Same | ||||||
| 16 | rs150210 | 21 | 19 362 312 | C/T | 0.25 | SBP | 1.1 | 0.30 | Opposite |
| DBP | 0.6 | 0.43 | Opposite | ||||||
| 17 | rs10910862 | 1 | 181 045 421 | T/C | 0.06 | SBP | 0.2 | 0.93 | Opposite |
| DBP | −0.1 | 0.96 | Same | ||||||
| 18 | rs2148117 | 10 | 27 213 946 | C/T | 0.05 | SBP | −0.6 | 0.80 | Same |
| DBP | 0.2 | 0.88 | Opposite | ||||||
| 19 | rs1150433 | 3 | 163 653 210 | T/C | 0.21 | SBP | 0.4 | 0.71 | Opposite |
| DBP | 0.0 | 0.98 | Same | ||||||
| 20 | rs969981 | 17 | 63 818 989 | T/C | 0.23 | SBP | 0.2 | 0.85 | Opposite |
| DBP | 0.1 | 0.86 | Opposite | ||||||
The loci are listed in the order of their rank in GENRES. All SNPs in this table were genotyped. CA indicates coded allele; CAF, coded allele frequency; Chr, chromosome; DBP, diastolic blood pressure; NCA, non‐coded allele; SBP, systolic blood pressure; SNP, single‐nucleotide polymorphism.