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. Author manuscript; available in PMC: 2016 Jan 31.

Published in final edited form as: Nanomedicine. 2014 Sep 3;11(2):447–456. doi: 10.1016/j.nano.2014.08.005

Survival curve for groups of 9 BALB/c mice challenged IN with 7 × LD₅₀ B. mallei China7, 3 weeks post-last IN immunisation with 3 × 50 μL doses of AuNP-FliC-LPS, AuNP-Hcp1-LPS, AuNP-TetHc-LPS or LPS alone (A). Body mass of immunised animals during the course of infection. Only AuNP-glycoconjugate immunised mice survived past day 7 (B). Colony counts of B. mallei in spleens three days post challenge. Each point is the mean of values from five mice. (C). Error bars represent the standard error of the mean; asterisks indicate significant differences (p < 0.001)

Survival curve for groups of 9 BALB/c mice challenged IN with 7 × LD₅₀ B. mallei China7, 3 weeks post-last IN immunisation with 3 × 50 μL doses of AuNP-FliC-LPS, AuNP-Hcp1-LPS, AuNP-TetHc-LPS or LPS alone (A). Body mass of immunised animals during the course of infection. Only AuNP-glycoconjugate immunised mice survived past day 7 (B). Colony counts of B. mallei in spleens three days post challenge. Each point is the mean of values from five mice. (C). Error bars represent the standard error of the mean; asterisks indicate significant differences (p < 0.001)