Table 5.
The amount of familial aggregation of melanoma explained by MC1R variants, pigmentation and nevi, from case-unrelated-control analyses
| Confirmed family history of melanoma | Cases / controlsa | ORb | OR adj for MC1Rc | OR adj for pigmentation and nevid | OR adj for all factorse |
|---|---|---|---|---|---|
| 1st degree relative | |||||
| No | 509/388 | 1.00 | 1.00 | 1.00 | 1.00 |
| Yes | 56/21 | 2.08 (1.21–3.60) | 1.79 (1.02–3.14) | 1.73 (0.98–3.07) | 1.59 (0.89–2.84) |
a
Population controls and spouse/friend controls.
b
Unconditional logistic regression, adjusted for age, sex, city of recruitment, and European ancestry.
c
Adjusted for the factors in footnote b, plus MC1R as per R allele and per r allele variables.
d
Adjusted for the factors in footnote b, plus pigmentation score (continuous) and nevus density (4 categories).
e
Adjusted for the factors in footnote b, plus MC1R, pigmentation score (continuous) and nevus density (4 categories).