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KO of Wnt16 Decreases Cortical but Not Trabecular Bone Volume
| Parameter | Age, wk | WT | KO | Change, % | P Value |
|---|---|---|---|---|---|
| LV5 Tb.BV/TV (%) | 16 | 14.8 ± 0.7 | 19.4 ± 1.0 | 31 ↑ | .05 |
| LV5 Ct.BV/TV (%) | 16 | 18.9 ± 0.5 | 14.3 ± 0.6 | 24 ↓ | <.001 |
| LV5 Tb.BV/TV (%) | 24 | 15.6 ± 0.9 | 16.9 ± 0.8 | 8 ↑ | .35 |
| LV5 Ct.BV/TV (%) | 24 | 14.8 ± 0.4 | 12.1 ± 0.4 | 19 ↓ | .001 |
LV5 vertebral bodies of female mice were examined. BV is normalized to combined cortical (Ct.) plus trabecular (Tb.) TV. Data are means ± SEM for a minimum of 7 bones per group.
