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. 2015 Jan 5;156(3):869–881. doi: 10.1210/en.2014-1677

Figure 2.

Figure 2.

SR1001 preserves insulin expression. A, Representative immunofluorescence staining of islets from SR1001- or vehicle-treated mice (starting at 5 wk of age) showing insulin content (red) and reduced immune infiltration. B, mRNA expression of insulin (Ins) genes in the pancreas of the same mice depicted in panel A. Data from panels A and B were from mice that were 22 weeks of age at the time of analysis. C, Representative immunofluorescence staining of islets from SR1001- or vehicle-treated mice (starting at 10 wk of age) showing insulin content (red) and reduced immune infiltration. D, mRNA expression of insulin (Ins) genes in the pancreas of the same mice depicted in panel C. Data from panels C and D were from mice that were 24 weeks of age at the time of analysis. Images are presented at ×20 magnification. Data are mean ± SEM values (n = 5/group). *, P < .05. DAPI, 4′,6′-diamino-2-phenylindole.

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