Figure 8.
SR1001 inhibits proinflammatory cytokine expression in the pancreas of NOD mice and increases the frequency of splenic CD4+ Foxp3+ T cells. mRNA expression of TH17 cytokines, IFNγ, and Foxp3 in the pancreas of 30-day treated SR1001 or vehicle-treated mice (A) is shown. Mice were either 5 or 10 weeks of age at the start of the experiment and 9 or 14 weeks of age at the termination of the experiment, respectively (n = 10/group). FACS analysis was performed of splenic CD4+ T cells expressing Foxp3 in 30-day (B) and long-term (C)-treated SR1001- and vehicle-treated NOD mice. Mice were either 9 or 24 weeks of age at the termination of the experiment, respectively. Data are mean ± SEM values (n = 5–8/group). *, P < .05.