Table 2.
Highly Sexually Dimorphic Hepatic Genes in Wild-Type C57BL/6J Mice Revealed by Microarray
| Gene symbol | Gene name | P value (FDR) | Male:female Log2 FC | Previous reference |
|---|---|---|---|---|
| Female predominant | ||||
| Xist | Inactive X-specific transcripts | 6.82E-07 | −7.85 | 43, 44 |
| Cyp2b9 | Cytochrome P450, family 2, subfamily b, polypeptide 9 | 2.29E-09 | −7.18 | 41, 43, 44 |
| Sult3a1 | Sulfotransferase family 3A, member 1 | 8.56E-08 | −7.13 | 41–44 |
| Slc22a26 | Solute carrier family 22 (organic cation transporter), member 26 | 2.51E-12 | −7.10 | 41–44 |
| Fmo3 | Flavin containing monooxygenase 3 | 3.26E-08 | −6.94 | 41–44 |
| Cyp2b13 | Cytochrome P450, family 2, subfamily b, polypeptide 13 | 3.69E-06 | −6.80 | 41, 43, 44 |
| Sult2a2 | Sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2 | 2.46E-04 | −5.93 | 41–44 |
| Hao2 | Hydroxyacid oxidase 2 | 5.86E-09 | −5.92 | 41–44 |
| AI132709 | Expressed sequence AI132709 | 7.15E-10 | −5.73 | None |
| Acot3 | Acyl-CoA thioesterase 3 | 1.94E-04 | −4.83 | 41, 43, 43 |
| Cyp3a41 | Cytochrome P450, family 3, subfamily a, polypeptide 41 | 4.56E-04 | −4.78 | 41, 43, 44 |
| Rad51b | RAD51 homolog B | 9.28E-05 | −4.70 | 41, 44 |
| Slc22a27 | Solute carrier family 22, member 27 | 5.84E-08 | −4.56 | 41 |
| Slc22a29 | Solute carrier family 22. member 29 | 2.09E-06 | −4.19 | 44 |
| Tcf24 | Transcription factor 24 | 7.46E-10 | −4.15 | None |
| Abcd2 | ATP-binding cassette, subfamily D (ALD), member 2 | 3.82E-07 | −4.05 | 41–44 |
| Cux2 | Cut-like homeobox 2 | 7.35E-06 | −3.69 | 41–44 |
| Nipal1 | NIPA-like domain containing 1 | 9.94E-04 | −3.10 | 41–44 |
| Cyp17a1 | Cytochrome P450, family 17, subfamily a, polypeptide 1 | 0.004 | −3.07 | 41–44 |
| Fam19a2 | Family with sequence similarity 19, member A2 | 7.17E-07 | −3.05 | 43, 44 |
| Cyp3a16 | Cytochrome P450, family 3, subfamily a, polypeptide 16 | 0.016 | −3.00 | 41–44 |
| Nt5e | 5′ nucleotidase, ecto | 1.14E-05 | −3.00 | 41–44 |
| Male predominant | ||||
| Cyp4a12 | Cytochrome P450, family 4, subfamily a, polypeptide 12 | 2.68E-06 | 7.37 | 41–44 |
| Ddx3y | DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked | 5.71E-12 | 6.75 | 41–44 |
| Hsd3b5 | Hydroxy-δ-5-steroid dehydrogenase, 3 β- and steroid δ-isomerase 5 | 3.24E-04 | 6.58 | 41–44 |
| Eif2s3y | Eukaryotic translation initiation factor 2, subunit 3, structural gene Y linked | 9.44E-11 | 6.18 | 41, 43, 44 |
| Ugt2b38 | UDP glucuronosyltransferase 2 family, polypeptide B38 | 2.68E-06 | 5.26 | 41–44 |
| Scara5 | Scavenger receptor class A, member 5 (putative) | 4.71E-04 | 4.73 | 41–44 |
| Nat8 | N-acetyltransferase8 (GCN5 related, putative) | 3.84E-08 | 4.67 | 41–44 |
| Elovl3 | Elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 | 0.003 | 4.38 | 41–44 |
| Cyp2d9 | Cytochrome P450, family 2, subfamily d, polypeptide 9 | 0.003 | 3.52 | 41, 43, 44 |
| Kdm5d | Lysine (K)-specific demethylase 5D | 5.84E-08 | 3.33 | 41–44 |
| C6 | Complement component 6 | 3.48E-06 | 3.20 | 41–44 |
| Cyp7b1 | Cytochrome P450, family 7, subfamily b, polypeptide 1 | 1.07E-08 | 3.10 | 41–44 |
All genes with FDR < 0.05 and Log2(fold change) > I3I are shown and listed in order of fold change from highest to lowest. Genes with multiple probes on the microarrays are listed only once. The indicated references are for previous studies that reported the same pattern of expression.