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E2 exerts negative feedback effects on LH in long-term OVX WT and KERαKO mice. Mean plasma LH levels from WT and KERαKO female mice that were bilaterally OVX and implanted with a capsule containing vehicle (V) or E2. Blood was collected 3 weeks after OVX. *, P < .05; **, P < .01; ***, P < .001. All data represented as mean ± SEM.
