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E2 induces LH surges in OVX WT, but not KERαKO, mice. Mean plasma LH levels from female WT and KERαKO mice that were bilaterally OVX, implanted with a capsule containing vehicle (V) or E2, and injected sc with vehicle or EB 6 days after OVX. Blood was collected after lights off (7:10–7:30 pm) 7 days after OVX. **, P < .01 compared with V-treated mice. All data represented as mean ± SEM.
