Table 2.
ECG Parameters at PND56 Male and Female CD-1 Mice
| ECG Parameter | Sex | Control | BPA 0.03 | BPA 0.3 | BPA 3.0 | BPA 30 | BPA 300 | EE 0.0001 | EE 0.001 | EE 0.01 |
|---|---|---|---|---|---|---|---|---|---|---|
| RR | M | 71.9 ± 2.0 (14) | 74.4 ± 2.4 (14) | 74.2 ± 2.6 (14) | 73.1 ± 2.9 (15) | 73.9 ± 3.0 (14) | 74.2 ± 3.2 (16) | 74.5 ± 2.7 (15)a | 73.8 ± 2.3 (17) | 72.5 ± 3.1 (15) |
| F | 72.6 ± 3.0 (15) | 74.2 ± 3.2 (14) | 73.7 ± 2.6 (17) | 73.0 ± 3.0 (17) | 74.4 ± 2.8 (13) | 73.5 ± 3.2 (16) | 72.4 ± 1.4 (16) | 74.1 ± 2.8 (16) | 73.1 ± 2.5 (16) | |
| PQ | M | 17.6 ± 2.3 (15) | 19.6 ± 2.9 (14) | 19.2 ± 2.8 (14) | 19.7 ± 3.1 (15) | 19.3 ± 2.4 (14) | 19.3 ± 2.5 (16) | 20.2 ± 2.7 (16)a | 20.2 ± 1.8 (17)a | 19.1 ± 1.9 (15) |
| F | 18.9 ± 2.2 (15) | 17.8 ± 2.8 (14) | 20.6 ± 1.7 (17) | 18.1 ± 3.5 (17) | 18.9 ± 2.9 (14) | 19.1 ± 3.3 (17) | 19.1 ± 2.9 (16) | 19.2 ± 3.2 (16) | 20.0 ± 1.7 (14) | |
| PR | M | 24.3 ± 2.2 (15) | 26.4 ± 2.9 (14) | 25.8 ± 3.0 (14) | 26.0 ± 3.5 (15) | 26.2 ± 2.6 (14) | 26.0 ± 2.8 (16) | 26.8 ± 2.7 (16)a | 26.8 ± 1.8 (17)a | 25.8 ± 2.0 (15) |
| F | 25.5 ± 2.5 (15) | 24.6 ± 2.9 (14) | 27.5 ± 1.7 (17) | 25.5 ± 2.9 (16) | 25.9 ± 2.8 (14) | 25.8 ± 3.5 (17) | 26.2 ± 2.4 (15) | 26.1 ± 3.2 (16) | 26.7 ± 2.2 (14) | |
| QRS | M | 10.1 ± 0.4 (15) | 10.2 ± 0.4 (13) | 10.3 ± 0.8 (14) | 9.9 ± 0.6 (15) | 10.3 ± 0.5 (14) | 10.2 ± 0.6 (16) | 10.1 ± 0.5 (16) | 10.2 ± 0.7 (17) | 10.2 ± 0.7 (15) |
| F | 10.2 ± 0.4 (14) | 10.6 ± 0.6 (14) | 10.4 ± 0.4 (17) | 10.3 ± 0.6 (17) | 10.4 ± 0.7 (12) | 10.5 ± 0.7 (16) | 10.1 ± 0.7 (16) | 10.4 ± 0.8 (16) | 10.2 ± 0.7 (14) | |
| QTc | M | 44.1 ± 2.1 (15) | 43.4 ± 1.9 (13) | 44.9 ± 1.9 (14) | 44.7 ± 2.0 (15) | 45.1 ± 2.5 (14) | 44.5 ± 2.0 (16) | 45.2 ± 1.3 (16) | 44.1 ± 2.0 (17) | 43.9 ± 1.5 (15) |
| F | 43.6 ± 2.1 (15) | 44.2 ± 2.4 (14) | 45.0 ± 2.4 (17) | 44.3 ± 2.5 (17) | 44.6 ± 2.5 (14) | 44.0 ± 3.3 (17) | 44.3 ± 1.9 (16) | 44.7 ± 2.7 (16) | 44.1 ± 1.3 (14) | |
| ST | M | 27.9 ± 2.0 (15) | 28.1 ± 2.5 (14) | 28.9 ± 2.6 (14) | 28.8 ± 2.2 (15) | 29.0 ± 2.2 (14) | 28.6 ± 2.0 (16) | 29.5 ± 1.8 (16)a | 28.2 ± 1.6 (17) | 27.7 ± 1.6 (15) |
| F | 27.5 ± 2.1 (15) | 28.0 ± 2.2 (14) | 28.8 ± 2.3 (17) | 28.0 ± 2.2 (17) | 28.1 ± 1.9 (13) | 27.6 ± 2.6 (16) | 28.0 ± 1.4 (16) | 28.9 ± 2.1 (15) | 28.3 ± 1.3 (14) |
Abbreviations: F, female; M, male. Values listed are in milliseconds and represent the group mean ± SD; n = is shown in parentheses.
a
Dunnett's multiple comparison test found values were significantly different from control (P < .05). Exposures are described in parts per million of diet.