. 2015 Jan 16;156(3):882–895. doi: 10.1210/en.2014-1847

Table 3.

Effects of Exposures and Iso Treatment

Treatment	Control	BPA 0.03	BPA 0.3	BPA 3.0	BPA 30	BPA 300	EE 0.0001	EE 0.001	EE 0.01
Male
Pretreatment body weight, g
Sham	39.3 ± 3.4	42.2 ± 5.3	40.0 ± 3.8	41.8 ± 2.9	41.0 ± 4.5	41.3 ± 3.9	42.1 ± 4.4	41.8 ± 4.9	38.2 ± 3.9
Iso	38.1 ± 3.5	42.8 ± 5.9	39.3 ± 5.7	42.4 ± 1.7	40.8 ± 4.5	41.5 ± 2.4	40.6 ± 6.0	40.3 ± 4.1	39.4 ± 3.3
Necropsy body weight, g
Sham	37.8 ± 3.9	39.0 ± 4.7	39.8 ± 1.8	40.5 ± 3.2	39.2 ± 3.9	39.5 ± 4.9	41.2 ± 4.9	40.4 ± 3.8	37.8 ± 3.8
Iso	36.4 ± 4.1	41.1 ± 4.4^a	38.7 ± 4.5	39.6 ± 4.0	38.3 ± 4.5	39.9 ± 2.8	39.9 ± 4.7	38.8 ± 4.3	37.6 ± 3.5
Heart weight, g
Sham	0.208 ± 0.014	0.213 ± 0.021	0.225 ± 0.019	0.244 ± 0.026^a	0.304 ± 0.058^a	0.209 ± 0.017	0.241 ± 0.034	0.240 ± 0.028	0.233 ± 0.051
Iso	0.231 ± 0.021^b	0.257 ± 0.027^b	0.224 ± 0.027	0.258 ± 0.031	0.262 ± 0.048	0.304 ± 0.058^a	0.264 ± 0.026	0.263 ± 0.054^b	0.247 ± 0.013^b
LV wall thickness, mm
Sham	1.043 ± 0.096	1.127 ± 0.186	1.136 ± 0.167	1.349 ± 0.161^a	1.192 ± 0.149	1.216 ± 0.210	1.188 ± 0.128	1.116 ± 0.153	1.172 ± 0.110
Iso	1.398 ± 0.262^b	1.126 ± 0.081^a	1.126 ± 0.115^a	1.234 ± 0.148	1.194 ± 0.162	1.104 ± 0.173^a	1.073 ± 0.077^a	1.124 ± 0.093^a	1.113 ± 0.033^a
Pericardial fat, g
Sham	0.047 ± 0.016	0.078 ± 0.022^a	0.068 ± 0.018^a	0.064 ± 0.016^a	0.066 ± 0.018	0.054 ± 0.022	0.061 ± 0.014	0.063 ± 0.015	0.056 ± 0.021
Iso	0.050 ± 0.025	0.059 ± 0.018^b	0.053 ± 0.023^b	0.046 ± 0.014^b	0.053 ± 0.018^b	0.052 ± 0.015	0.056 ± 0.015	0.052 ± 0.016	0.047 ± 0.015
Female
Pretreatment body weight, g
Sham	28.3 ± 2.5	30.2 ± 3.8	30.7 ± 4.7	32.6 ± 3.4^a	33.0 ± 3.6^a	33.1 ± 4.8^a	35.7 ± 6.9^a	33.3 ± 1.9^a	30.2 ± 3.6
Iso	28.6 ± 1.7	30.3 ± 3.6	30.8 ± 3.8	32.3 ± 2.6^a	31.4 ± 2.9	32.2 ± 2.8^a	35.5 ± 5.4^a	32.7 ± 5.7	29.9 ± 4.0
Necropsy body weight, g
Sham	28.0 ± 3.2	29.6 ± 3.9	29.8 ± 3.1	31.4 ± 3.1^a	31.7 ± 3.9^a	31.5 ± 3.5^a	33.3 ± 6.3^a	31.5 ± 3.3	28.7 ± 2.2
Iso	28.8 ± 2.0	30.0 ± 3.3	28.7 ± 2.9	31.2 ± 3.0	29.8 ± 3.9	30.5 ± 3.6	31.3 ± 5.0	29.5 ± 4.6	26.4 ± 2.8
Heart weight, g
Sham	0.176 ± 0.013	0.180 ± 0.017	0.180 ± 0.029	0.185 ± 0.037	0.188 ± 0.027	0.199 ± 0.036	0.183 ± 0.030	0.170 ± 0.026	0.145 ± 0.016
Iso	0.204 ± 0.015^b	0.215 ± 0.040^b	0.229 ± 0.026^b	0.216 ± 0.025^b	0.221 ± 0.035	0.211 ± 0.029	0.218 ± 0.028^b	0.225 ± 0.030^b	0.179 ± 0.001
LV wall thickness, mm
Sham	1.110 ± 0.126	1.047 ± 0.115	1.062 ± 0.110	1.062 ± 1.115	1.085 ± 0.164	1.082 ± 0.116	1.058 ± 0.112	1.088 ± 0.141	1.020 ± 0.149
Iso	1.024 ± 0.076	1.175 ± 0.078^a	1.039 ± 0.023	1.115 ± 0.086	1.006 ± 0.101	1.125 ± 0.121	1.092 ± 0.141	1.073 ± 0.078	1.008 ± 0.110
Pericardial fat, g
Sham	0.069 ± 0.016	0.063 ± 0.019	0.072 ± 0.015	0.079 ± 0.014	0.079 ± 0.014	0.073 ± 0.020	0.077 ± 0.024	0.079 ± 0.032	0.086 ± 0.032
Iso	0.044 ± 0.017^b	0.057 ± 0.016^a,b	0.062 ± 0.016^a,b	0.064 ± 0.017^a,b	0.052 ± 0.008^a,b	0.061 ± 0.018^a	0.054 ± 0.017^a,b	0.063 ± 0.022^a,b	0.047 ± 0.011^b

Values represent group mean ± SD.

Significantly different from control within treatment.

Significantly different from sham group in the same diet (P < .05 as assessed by ANCOVA or ANOVA where appropriate).