Table 3.

Evidence of association for ESRRG rs2818964 with hearing status in Isolated Populations Cohort

Quantitative trait	Combined populations			Carlantino project			Silk Road			Friuli Venezia Giulia project
(n)	p value	Trend directiona	(n)	p value	Trend directiona	(n)	p value	Trend directiona	(n)	p value	Trend directiona
Female 0.125 kHz	804	0.0638	G	171	0.0795	G	No data	No data	No data	633	0.2390	G
Female 0.25 kHz	977	0.4509	G	172	0.0172	G	171	0.5018	G	634	0.9847	A
Female 0.50 kHz	977	0.2563	G	172	0.0262	G	171	0.1020	G	634	0.3235	A
Female 1 kHz	977	0.0157	G	172	0.0286	G	171	0.7825	G	634	0.0577	A
Female 2 kHz	976	0.0640	G	172	0.0065	G	170	0.2899	G	634	0.1875	A
Female 4 kHz	962	0.4220	G	172	0.2290	G	171	0.5997	G	619	0.5483	A
Female 8 kHz	947	0.3370	G	172	0.6325	G	171	0.7240	G	604	0.2844	A
Female PTAlow	977	0.1454	G	172	0.0156	G	171	0.2886	G	634	0.3157	A
Female PTAmedium	977	0.0385	G	172	0.0101	G	171	0.2401	G	634	0.0889	A
Female PTAhigh	962	0.3582	G	172	0.4407	G	171	0.6116	G	619	0.3471	A
Male 0.125 kHz	547	0.5105	G	120	0.6431	G	No data	No data	No data	427	0.6330	G
Male 0.25 kHz	674	0.4498	G	121	0.2777	A	126	0.7735	G	427	0.1943	G
Male 0.50 kHz	674	0.0847	G	121	0.6631	G	126	0.3915	G	427	0.1558	A
Male 1 kHz	674	0.1362	G	121	0.4953	G	126	0.9596	G	427	0.1556	G
Male 2 kHz	674	0.8231	A	121	0.8827	A	126	0.2542	G	427	0.7008	A
Male 4 kHz	667	0.5413	G	121	0.5997	A	126	0.0850	G	420	0.0568	A
Male 8 kHz	659	0.7290	A	121	0.4821	A	126	0.4501	G	412	0.7326	A
Male PTAlow	674	0.1692	G	121	0.9900	A	126	0.6938	G	427	0.1460	G
Male PTAmedium	674	0.4879	G	121	0.7997	G	126	0.6869	G	427	0.3584	A
Male PTAhigh	667	0.7590	G	121	0.4522	A	126	0.3115	G	420	0.1991	A

^aAllele associated with poorer hearing thresholds. Association analysis was conducted using mixed model linear regression; p values that are significant at the 5% level are shown in bold.