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. 2015 Jan 12;43(3):1332–1344. doi: 10.1093/nar/gku1290

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — (a) Driver mutational event in a subset of patients caused by selection, with a selected expression regulator (SER) mediating the effect of the driver mutant. The SER is correlated with genes under similar selection across patients. After conditioning on the SER, the correlation among the genes disappears. (b) There are many driver events across patients that target different pathways, depending on the selection pressure in different patients. The goal is to identify which SER best explains these patterns of expression.