Table 1. Association between expression of PYCARD and response to obatoclax therapy for the log10 IC50 estimated from obatoclax dosage response curves.
| log10 IC50 | Patients (n = 30) | ||
|---|---|---|---|
| Model | Variable | β (95% CI) | P-value |
| Univariate OLS | PYCARD | −0.37 (−0.71, −0.032) | 0.033 |
| Bivariate OLS | PYCARD | −0.45 (−0.73, −0.17) | 0.0025 |
| CR | 0.52 (0.25, 0.79) | 0.00051 | |
| Univariate robust | PYCARD | −0.38 (−0.74, −0.019) | 0.04 |
| Bivariate robust | PYCARD | −0.43 (−0.7, −0.16) | 0.0029 |
| CR | 0.59 (0.33,0.85) | 0.000077 | |
We used two regression methods, ordinary least squares (OLS) and robust regression, to test for an association between PYCARD expression and obatoclax sensitivity. To control for potential, a potential confounder in terms of good versus poor responders, whether or not the patient experienced a complete response (CR) from the therapy they were given (in this case not obatoclax) was also included in the model.