Table 1.
Flotillin-1 SILAC LTQ-Orbitrap-MS: list of proteins significantly down-regulated (>20 %) by shFlot-1 relative to shGFP in the detergent-resistant membrane of HUVECs (n = 3)
| Protein | Accession | Score | Mean heavy/light | SEM | |
|---|---|---|---|---|---|
| Flot1 | Flotillin-1 | O75955 | 1,934 | 0.10 | 0.04 |
| Flot2 | Flotillin-2 | Q14254 | 1,794 | 0.11 | 0.05 |
| CAV1 | Caveolin-1 | Q03135 | 1,362 | 0.62 | 0.05 |
| CAVIN1 | Cavin-1 | Q6NZI2 | 1,111 | 0.69 | 0.08 |
| ERLN2 | Erlin-2 | O94905 | 793 | 0.58 | 0.10 |
| VDAC2 | Isoform 2 of voltage-dependent anion-selective channel protein 2 | P45880-2 | 623 | 0.74 | 0.01 |
| SERPH | Serpin H1 | P50454 | 512 | 0.63 | 0.04 |
| PGK1 | Phosphoglycerate kinase 1 | P00558 | 419 | 0.55 | 0.11 |
| CAVIN2 | Cavin-2 | O95810 | 418 | 0.67 | 0.06 |
| LDHB | L-lactate dehydrogenase B chain | P07195 | 333 | 0.59 | 0.18 |
| CATD | Cathepsin D | P07339 | 268 | 0.73 | 0.04 |
| VINC | Vinculin | P18206-2 | 167 | 0.66 | 0.04 |