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. 2015 Feb 16;30(3):308–316. doi: 10.3346/jkms.2015.30.3.308

Fig. 3.

Fig. 3

Wound healing assay and invasion assay of the UC cell lines treated with siRNA oligonucleotides directed against pS6K or elF4E or a high concentration of rapamycin. (A) Inhibiting phosphorylation of both pS6K and elF4E by rapamycin reduce cell migration more than transfection of siRNA against pS6K or elF4E in KU-7 cells. (B) An invasion assay was performed to evaluate the effect of rapamycin, pS6K, and elF4E siRNA on bladder cancer cells invasion. Cells silenced for pS6K or elF4E expression exhibit significantly reduced cell invasion compared to that of the control (P < 0.05) but inhibiting phosphorylation of both pS6K and elF4E by rapamycin reduced cell invasion more than the transfection of siRNA against pS6K or elF4E in KU-7 cells. *P < 0.05; †P < 0.01.