Fig. 4.

The effects of S6K1 and Elf4E dual inhibition to control bladder cancer progression at orthotopic mouse non-muscle invasive bladder cancer model. (A) In vivo imaging of tumor growth over time according to groups. After intravesical instillation of 2×10⁶ Ku-7-Luc cells on day zero, mice are imaged at 4, 7, 14, and 21 days. (B) Comparison of bioluminescence between groups. The photon densities of control showed higher than other groups at 17 and 21 days. (C) Comparison of tumor volumes between groups. The groups with pS6K or elF4E siRNA instillation show the decreased tumor volumes compared to control, but the groups with dual pS6K and elF4E siRNA and rapamycin instillation reduce tumor volumes more than the groups with pS6K or elF4E siRNA instillation. ^*P < 0.05; ^†P < 0.01.