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. 2014 Nov 12;40(4):927–937. doi: 10.1038/npp.2014.268

Figure 5.

Figure 5

Pioglitazone prevents morphine effects on RMTg-induced inhibition of VTA DA neurons. (a) Acute bath application of morphine at a concentration of 1 μM (3 min) significantly reduced IPSCs evoked by RMTg stimulation by 40.8±4.3%. (b) Increased paired-pulse ratio (from IPSC2/IPSC1=1.02±0.06 to IPSC2/IPSC1=1.53±0.11) following acute morphine application; (c) The effects of morphine was fully abolished when the slices were incubated with pioglitazone (30 μM, 2 h); hence, morphine failed to reduce GABAA-IPSCs (106.8±16.3% of basal). (d) Morphine failed to modify the paired-pulse ratio (from IPSC2/IPSC1=1.3±0.4 to IPSC2/IPSC1=1.1±0.3) in slices pre-incubated with pioglitazone.