Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Nov 12;40(4):927–937. doi: 10.1038/npp.2014.268

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 American College of Neuropsychopharmacology

PMC Copyright notice

Pioglitazone attenuates operant heroin self-administration following site-specific microinjection into the RMTg, but not into the VTA. (a) Effect of intra-RMTg injections of pioglitazone (0 or 5 μg/0.6 μl) in rats (N=18) subjected to heroin FR-1 self-administration. Values represent the mean (±SEM) number of infusions (panel a) and responses at inactive lever (panel b). (b) Schematic representation showing correct (filled circles) and incorrect (unfilled triangles) cannulae placements. (c) Effect of intra-VTA injections of pioglitazone (0 or 5 μg/0.6 μl) in rats (N=17) subjected to heroin FR-1 self-administration. Values represent the mean (±SEM) number of infusions (panel a) and responses at inactive lever (panel b). (d) Schematic representation showing correct (filled circles) and incorrect (unfilled triangles) cannulae placements. Drawing is from the atlas of Paxinos and Watson. Significant difference from controls (0.0) *p<0.05.