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. 2015 Feb 17;5:8505. doi: 10.1038/srep08505

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(a) MiRNAs extracted from E-EVs undergo a drastic change following treatment with inflammatory stimulants. Some of the miRNAs are upregulated more than 500 fold by CytoCombo + LPS treatment when compared to the non-stimulated control. (b) The multifunctional transcription factor Yy1 is determined as a target of let-7d-3p in mice that are commonly identified in 3 different public accessible databases. (c) Homology analysis of let-7d-3p. The alignment of let-7d-3p sequences indicates that the mature sequences of five mammalian species are identical. (d) YY1, ABCA8, and RLN2 are determined as a target of let-7d-3p in human that are commonly identified in 3 different public accessible databases.