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Structure of TIR1-ASK1 in a Complex with IAA and the Degron Peptide from IAA7.
TIR1-ASK1 structure as described by Tan et al. (2007). ASK1 (green) interacts with TIR1 (red) through the F-box domain. IAA (blue) is present in the auxin binding pocket and acts to stabilize the interaction between TIR1 and the degron peptide (pale cyan). A single InsP6 molecule (pale orange) is bound to TIR1 beneath the auxin binding pocket.
