Figure 2.

Interrelation between nitric oxide and mitochondria in adipose tissue in metabolic syndrome. The proinflammatory microenvironment of adipose tissue induces the iNOS activity in MS that increases peroxynitrite synthesis, thus contributing to oxidative stress and chronic inflammation. Under the influence of these conditions the reduced expression of the mitochondrial protein UCP-2 promotes the formation of MS components through decreased NO bioavailability and increased ROS generation. Reduction in the expression of mitochondrial transcription factor A also contributes to the development of MS components.