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Molecular dynamics simulation of the WT (left panel) and the p.I141V mutants (right panel) of Nav1.4 channel. In the presence of the p.I141V mutation, the model predicted the formation of a hydrogen bond (Green arrow) between the S2-Y168 and S4-R225 residues, thus stabilizing the open confirmation of the channel; (From Amarouch et al., 2014).
