Table 3:

Smoking Cessation Therapies

	Benefits vs Placebo	Optimal Dose	Side Effects	Combination vs Single Agent Therpay
Nicotine Replacement Therapy (NRT)	2 fold increase in smoking cessation compared to placebo	Depends on amount of cigarettes smoked/ day at quit date	Insomnia, disturbing dreams, nasal irritation(for nicotine nasal sprays)	Combination long and short acting NRT more successful than single agent
Bupropion	2 fold increase in smoking cessation compared to placebo	150mg po bid x 7-12weeks	Insomnia, lowers seizure threshold, suicidal thoughts/ actions	Bupropion + NRT more successful than either agent alone
Varenicline	2-4 fold increase in smoking cessation compared to placebo	1mg po bid x 12 weeks	Insomnia, depression, suicidal thoughts/ actions, disturbing dreams, GI side effects	Conflicting data on superiority of varenicline + NRT vs varenicline alone
E-cigarettes	Unclear at present time, further studies required	N/A	Unregulated	N/A