Table 5:

Contraindication to Lung Transplant from 2006 ISHLT Guidelines

Absolute and relative contraindications for lung transplantation

Absolute contraindications: Malignancy in the last 2 years, with the exception of cutaneous squamous and basal cell tumors Untreatable advanced dysfunction of another major organ system Noncurable chronic extrapulmonary infection, including chronic active HBV, HCV and HIV Significant chest wall or spinal deformity Documented nonadherence or inability to follow through with medical therapy or office follow-up, or both Untreatable psychiatric or psychologic condition associated with the inability to cooperate or comply with medical therapy Absence of a consistent or reliable social support system Substance addiction that is either active or within the last 6 months

Relative contraindications: Age older than 65 years Critical or unstable clinical condition (e.g., shock, mechanical ventilation or ECMO) Severely limited functional status with poor rehabilitation potential Colonization with highly resistant or highly virulent bacteria, fungi or mycobacteria Severe obesity defined as a BMI exceeding 30 kg/m2 Chronic mechanical ventilation Unstable extrapulmonary medical conditions that have not resulted in end-stage organ damage