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. 2015 Feb 17;9:31. doi: 10.3389/fnbeh.2015.00031

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Copyright © 2015 Albani, Andrawis, Abella, Fulghum, Vafamand and Dumas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Plasma CORT concentrations measured at baseline and after EPM exposure. (A) Baseline CORT levels during diurnal AM and PM. 4–7 animals were represented in each TOD category per age group. (B) Impact of TOD and age on CORT levels in maze-exposed rats (P17–19: AM, n = 9; PM, n = 6; P22–24: AM, n = 13 and PM, n = 15). CORT concentrations were higher after testing at P17–19 compared to P22–24, regardless of whether tested during the AM (Tukey HSD: p = 0.012) or PM (Tukey HSD: p < 0.001). (C) CORT in maze-exposed rats plotted against time of testing. *p < 0.05.