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. 2015 Feb 17;9:8. doi: 10.3389/fncel.2015.00008

Figure 4.

Figure 4

Similar gain-of-function of excitatory neurotransmission at cortical pyramidal cell autapses of homozygous SL/SL and heterozygous SL/WT KI mice. (A) Average value of EPSC amplitudes evoked in single SL/SL and SL/WT cortical pyramidal cells in microculture (DIV 10–14). EPSC amplitudes: 5.2 ± 0.5 nA in SL/SL (n = 46) and 6.3 ± 0.5 nA in SL/WT (n = 95) neurons (t-test: p = 0.14). (B) PPR evoked by two depolarizing stimuli at 50 Hz in cortical pyramidal cells in microculture (DIV 10–14) from SL/SL (n = 36) and SL/WT KI mice (n = 43). PPR: 0.65 ± 0.03 and 0.71 ± 0.03 in SL/SL and SL/WT neurons, respectively (t-test: p = 0.15). (C) Normalized EPSC amplitudes as a function of extracellular [Ca2+] evoked in cortical pyramidal cells in microculture (DIV 10–14) from SL/SL (n = 10) and SL/WT KI (n = 11) mice. The average normalized EPSC data points were fitted with EC50 = 0.99 mM, n = 2.1 for SL/SL KI mice and EC50 = 0.87 mM, n = 2.2 for SL/WT KI mice.