Table 1.
NEK2A interaction proteins and their functions.
NEK2A interaction protein | Detection method | Function | Reference number |
---|---|---|---|
APC/C | Co-IP | NEK2A degradation | [23] |
PP1 | Yeast two-hybrid, Co-IP | NEK2A dephosphorylation | [26, 27] |
C-Nap1 | Yeast two-hybrid | Centrosome separation | [28] |
Rootletin | Yeast two-hybrid | Centrosome separation | [29] |
NLP2 | Yeast two-hybrid | Microtubule organization | [33] |
Numatrin | Co-IP, pull-down | Centrosome integrity and dynamics | [37] |
HMGA2 | Co-IP, pull-down | Chromatin condensation | [38] |
HEC1 | Co-IP | Spindle assembly checkpoint, chromosome separation | [42] |
MAD1 | Yeast two-hybrid, Co-IP | Spindle assembly checkpoint, chromosome separation | [40] |
TRF1 | Yeast two-hybrid, pull-down | Chromosome separation | [41] |
MAD2 | Co-IP | Spindle assembly checkpoint, chromosome separation | [12] |
SGO1 | Pull-down, Co-IP | Chromosome congression | [43] |