Table 3.

Signaling involved in the tumorigenic function of NEK2A.

Proteins or signaling pathways interact with NEK2A	The relationship with NEK2A	Function	Reference number
Upstream of NEK2A
MAPK pathway	Phosphorylate NEK2A	Tumorigenesis	[39]
MST2	Regulate NEK2A's ability to localize to centrosome and phosphorylate C-Nap1 and Rootletin	Tumorigenesis	[59]
PLK1	Regulate MST2-NEK2A/NEK2A-β-catenin-induced centrosome separation and NEK2A-NIP-induced microtubule organization	Tumorigenesis	[32, 60, 61]
CDK4	Regulate NEK2A expression	Tumorigenesis	[62]
Downstream of NEK2A
CDC20	Phosphorylated by NEK2A	Tumorigenesis	[63]
MAD2	Phosphorylated by NEK2A	Tumorigenesis	[63]
HEC1	Phosphorylated by NEK2A	Tumorigenesis	[42]
TRF1	Phosphorylated by NEK2A	Tumorigenesis	[64]
AKT	Phosphorylated by NEK2A	Tumor progression and drug resistance	[12]
β-Catenin	NEK2A induces nuclear accumulation of β-catenin	Tumor progression and drug resistance	[12]
ABCB1	Upregulated by NEK2A	Drug resistance	[12]
ABCC1	Upregulated by NEK2A	Drug resistance	[12]
ABCG2	Upregulated by NEK2A	Drug resistance	[12]
BAD	Downregulated by NEK2A	Drug resistance	[12]
PUMA	Downregulated by NEK2A	Drug resistance	[12]
BCL-XL	Upregulated by NEK2A	Drug resistance	[12]
MCL-1	Upregulated by NEK2A	Drug resistance	[12]
PARP	Activated in NEK2A silenced cancer cell	Drug resistance	[12]
Caspase-3	Activated in NEK2A silenced cancer cell	Drug resistance	[12]
Caspase-8	Activated in NEK2A silenced cancer cell	Drug resistance	[12]
Caspase-9	Activated in NEK2A silenced cancer cell	Drug resistance	[12]
RB	Activated in NEK2A silenced cancer cell	Drug resistance	[65]
Histone H3 (p-Ser10)	Inactivated in NEK2A silenced cancer cell	Drug resistance	[65]