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. 2015 Feb 1;2015:729831. doi: 10.1155/2015/729831

Figure 4.

Figure 4

TM-1 administered 3 or 4 h after injury reduced the TBI-induced AQP4 mRNA expression measured 8 and 24 h after TBI. (a) β-actin and (b) Gapdh as reference genes. AQP4 mRNA expression significantly decreased following TM-1 administration (10 mg/kg) 3 and 4 h after injury in the rats sacrificed 8 or 24 h after injury, respectively. Compared with the TBI + veh groups, the TM-1 treated groups exhibited significantly decreased mRNA expression. Data are expressed as mean ± SD (n = 5/group). *** P < 0.001 TBI + veh group compared with the sham-operated group; ## P < 0.01 and ### P < 0.001 compared with the TBI + veh groups; + P < 0.05, comparison between mRNA expression following TM-1 administration (10 mg/kg) 3 and 4 h after injury in the rats sacrificed 8 or 24 h after TBI.