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. 2015 Jan 16;34(4):517–530. doi: 10.15252/embj.201489574

Figure 3.

Figure 3

p53 inactivation enables NFATc1 to drive dedifferentiated PDAC
  1. Kaplan–Meier curves showing survival of KNC, KPNC, and KPΔNC mice under the control of p48-Cre pancreas-specific promoters (P < 0.0001 for KPNC or KPΔNC cohorts versus KNC, log-rank test, for pairwise combination).
  2. Pathological features of KPNC and KPΔNC mice before tumor extraction. Pancreatic tissue is encircled.
  3. H&E and corresponding immunohistochemical stainings of (C) KPNC and (D) KPΔNC mouse tumors. Scale bars, 100 μm.
  4. Tumor grading of PDAC from KPNC mice (n = 10).