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. Author manuscript; available in PMC: 2015 Feb 17.
Published in final edited form as: J Vet Intern Med. 2011 May 12;25(4):903–908. doi: 10.1111/j.1939-1676.2011.0730.x

Table 2.

Pharmacokinetic parameters of 4-OH-cyclophosphamide following IV or oral dosing in dogs.

PK Parametera Units IV Oral
AUC0→inf μg/h/mL 1.66 ± 0.36 1.42 ± 0.64
Cmax μg/mL 2.79 ± 1.34 1.21 ± 0.80*
t1/2λ hour 0.67 ± 0.45 0.59 ± 0.29
Tmax hour 0.22 ± 0.09 1.25 ± 0.65*
AUC/dose ng/h/mL/mg 7.60 ± 4.18 5.38 ± 2.63
Cmax/dose ng/mL/mg 10.3 ± 5.1 4.6 ± 3.3*

Pharmacokinetic parameters accompanied by standard deviation.

a

PK parameters were calculated by noncompartmental analysis.

*

Significantly different (P < .05) from IV dosing parameter as determined by Mann-Whitney analysis.