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Summary of Gd-based DSC methodology: staged injection technique. Gradient-echo DSC-MRI (0.1-mmol/kg gadodiamide bolus) provides no preload (P−) rCBV data and serves as a preload (P+) for subsequent DSC-MRI (0.2 mmol/kg bolus). Gd-rCBV without (C−) and with (C+) application of postprocessing leakage correction are computed for both P− and P+ data, thereby testing P−C−, P−C+, P+C−, and P+C+ permutations of the 2 leakage-correction techniques.
