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. Author manuscript; available in PMC: 2015 Feb 17.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2012 Aug 28;5(5):1017–1026. doi: 10.1161/CIRCEP.111.969220

Table 1.

Nav1.5 parameters

HEK-293 cells NRCMs
WT (n) D117N (n) WT (n) D117N (n)
Peak current density (pA/pF) (20) (19) (16) (13)
-265.1 [-306.4; -181.8] -142. 2[-207.0; -82.7]* -756.8 [-1079.6; -545.5] -650.0 [-701.8; -576.0]
Activation (23) (18) (19) (11)
Vh (mV) -45.4[-52.2; -41.3] -36.7[-43.8; -30.3] † -46.8 [-51.6; -38.8] -32.1 [-39.4; -30.8]†
k 7.26[5.9; 8.4] 6.55[5.8; 8.1]* 7.3 [6.4; 7.7] 7.4 [7.1; 7.9]
Fast-inactivation (16) (19) (16) (8)
Vh (mV) -97.0[-103.0; -95.4] -92.8[-98.1; -90.9] † -95.7 [-101.9; -92.1] -85.7 [-99.9; -77.6] †
k 6.1[5.8; 6.5] 7.2[6.4; 7.8] 6.9 [6.1; 7.4] 7.5 [6.7; 7.8]

Vh, represents midpoint voltage of maximal activation/inactivation; k, slope factor; n, the number of patches.

*

p<0.05;

†

p<0.01 vs. ZASP1-wt.