Table 2.

Time-dependent parameters of Na_v1.5

	WT (n)	D117N (n)
Recovery from fast-inactivation	(10)	(8)
τf (ms)	4.2 [3.2; 5.2]	1.9 [1.8; 2.2]
τs (ms)	24.6 [22.2; 27.0]	54.0 [42.1; 61.1]*
Af (%)	0.3 [0.2; 0.3]	0.1 [0.1; 0.2]*
As (%)	0.9 [0.8; 0.9]	0.9 [0.9; 1.1]
Closed-state inactivation	(14)	(19)
τ (ms)	68.2 [50.4; 80.9]	81.8 [72.0; 113.4]*
Slow inactivation	(8)	(8)
τ (ms)	800.1 [761.4; 838.8]	1202.6 [1145.5; 1347.0]

τ_f and τ_s the time constants of fast and slow components of recovery; A_f and A_s, the fraction of fast and slow components; n, the number of patches.

^*p<0.05, vs. ZASP1-wt.