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. Author manuscript; available in PMC: 2015 Feb 17.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2012 Aug 28;5(5):1017–1026. doi: 10.1161/CIRCEP.111.969220

Table 3.

Effect of ML-7 and Cytochalasin D on Nav1.5 parameters

ML-7 Cytochalasin D
WT (n=15) D117N (n=10) WT (n=10) D117N (n=11)
Peak current density (pA/pF) -231.6 [-288.4; -193.9] -230.8 [-282.3; -159.1] -143.8 [-219.6; -120.2] -203.0 [-234.0; -177.3]
Activation
Vh (mV) -36.2 [-38.7; -35.2] -42.2 [-47.2; -39.4] -34.8 [-35.3; -26.9] -45.7 [-50.2; -36.2]
k 7.5 [5.7; 8.3] 7.4 [6.8; 7.8] 8.3 [7.1; 10.4] 6.7 [6.5; 7.4]
Fast-inactivation
Vh (mV) -99.9 [-104.6; -96.4] -95.0 [-101.7; -91.2] -93.9 [-103.0; -88.8] -97.9 [-106.0; -95.1]
k 6.8 [6.3; 7.2] 6.2 [5.6; 7.1] 7.1 [5.4; 7.7] 5.8 [5.6; 6.6]

Vh, represents midpoint voltage of maximal activation/inactivation; k, slope factor; n, the number of patches.