Fig 1. Effects of maternal antibiotic (ATB) treatment on colonic microbiota of offspring between 14 and 42 days of age (weaning at day 28).
(n = 5 per treatment). A. Principle Response Curve (PRC) showed no overall significant effects of maternal ATB treatment on colonic microbiota composition in offspring, however, the microbial composition of the ATB group showed a remarkable shift between day 21 and 28 especially for those microbial groups depicted in the B-panel. Cdt, canonical coefficient. B. The relative contribution of bacteria (red) with a positive species weight (bk) was lower in the ATB group compared to the treatment group on day 14 and 21, but increased between day 21 and 28, and decreased again after weaning at day 28; while those (black) with a negative species weight (bk) showed an opposite trend.