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. 2015 Feb 17;10(2):e0117555. doi: 10.1371/journal.pone.0117555

Fig 1. Excitatory neurotransmission onto the dentate gyrus granule cells is reduced in the granule cells from Aβ treated rats.

Fig 1

A, Spontaneous EPSCs were less frequent in the EC-Aβ (lower trace) than control (upper trace) neurons with unaltered kinetics. Far right panel shows the analysis of the time constant of rise and decay phases and examples of sEPSCs traces of granule cells from control and Aβ treated groups which were best fit with single exponential function. Cumulative probability plot (B) and mean amplitude (C) of spontaneous EPSCs were unaltered. D, cumulative probability plots showed that spontaneous events in the EC-Aβ neurons shifted to longer inter-event intervals (IEIs) (lower frequencies). E, Daily i.c.v. treatment by nimodipine produced a significant trend (p = 0.07) towards reversing decreased sEPSCs frequency (2.569 ± 0.25 Hz, n = 6 cells/4 rats) (Fig. 1D and E). Values are mean ± SEM. **p < 0.01 and ***p < 0.001 contrasted to the control cells. Control and EC-Aβ group, n = 6 cells/ 5 rats; EC-Aβ + ISR and EC-Aβ + NIM, n = 6 cells/ 4 rats.