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. Author manuscript; available in PMC: 2015 Feb 17.
Published in final edited form as: Ann Surg Oncol. 2008 Sep 25;15(12):3369–3377. doi: 10.1245/s10434-008-0153-2

Fig. 1.

Fig. 1

Lobular histology and lymphovascular invasion (LVI) in the primary tumor are associated with the detection of isolated tumor cells (ITC) in patients with early-stage breast cancer. (A) Hematoxylin and eosin (H&E) staining of a tumor from a patient with early-stage breast cancer demonstrating lobular histology. (B) Immunohistochemical (IHC) staining for cytokeratin of a sentinel lymph node (SLN) from the same patient demonstrates scattered foci of ITC staining brown. (C) H&E staining of a second patient's primary tumor demonstrating LVI. (D) IHC performed on the SLN from the second patient showing ITC.