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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2015 Jan 10;283(2):99–108. doi: 10.1016/j.taap.2014.12.017

Figure 2. Survival of C57BL/6 or Notch1ICN-TG mice following developmental exposure to 3μg/kg TCDD or vehicle control.

Figure 2

Pregnant C57BL/6 dams (paired with either C57BL/6 or Notch1ICN-TG males) were exposed to 3μg/kg TCDD or vehicle control throughout gestation (GD0.5, GD7.5, GD14.5, PPD2.5). Resulting offspring were followed through twelve weeks of age to determine age of death. C57BL/6 mice are represented with a black line (vehicle and TCDD; n=35). Notch1ICN-TG mice are represented with a red line (vehicle; n=72) or blue line (TCDD; n=63). Survival fractions were calculated using Kaplan-Meier analysis, and survival curves were compared using the log-rank (Mantel-Cox) test (C57BL/6 p=1.00; Notch1ICN-TG p=0.62).