Skip to main content
. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2015 Jan 10;283(2):99–108. doi: 10.1016/j.taap.2014.12.017

Figure 5. TCDD-exposed Notch1ICN-TG mice fail to develop Notch1-mediated splenomegaly.

Figure 5

Developmental exposure to TCDD in Notch1ICN-TG mice results in significantly smaller adult spleen size. Pregnant C57BL/6 dams were paired with Notch1ICN-TG males and exposed to 3μg/kg TCDD or vehicle control throughout gestation (GD0.5, GD7.5, GD14.5, PPD2.5). Vehicle treated mice are represented by a white bar and mice treated with TCDD are represented by a filled bar. Bars graph mean with SE. A single * indicates p ≤0.05; ** indicates p ≤0.01; *** indicates p ≤0.001. Comparisons of spleen weight (A), length (B), and width (C) were all made on 8 week old mice; spleen grading was done across all mice between 8–12 weeks of age at any age of necropsy. (n= 38 vehicle and 23 TCDD mice in A–C; n=61 vehicle and 52 TCDD mice in D)