. 2014 Sep 5;57(19):8140–8151. doi: 10.1021/jm501071f

Table 2. Inhibitory Activity of the Newly Designed and Obtained Phosphinic Dipeptide Analogs toward N. meningitides APN and Mammalian Aminopeptidases: Human APN, Porcine APN, and Porcine LAP, Compared to Lead Compounds hPhePψ[CH₂]Phe (1) and hPhePψ[CH₂]Tyr (2)^a.

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The most significant inhibition is highlighted in bold. Measurements were made after 30–60 min of incubation and calculated using Morrison’s equation for tight binding inhibitors (for details see the Supporting Information).

Table 2. Inhibitory Activity of the Newly Designed and Obtained Phosphinic Dipeptide Analogs toward N. meningitides APN and Mammalian Aminopeptidases: Human APN, Porcine APN, and Porcine LAP, Compared to Lead Compounds hPhePψ[CH2]Phe (1) and hPhePψ[CH2]Tyr (2)a.

Table 2. Inhibitory Activity of the Newly Designed and Obtained Phosphinic Dipeptide Analogs toward N. meningitides APN and Mammalian Aminopeptidases: Human APN, Porcine APN, and Porcine LAP, Compared to Lead Compounds hPhePψ[CH₂]Phe (1) and hPhePψ[CH₂]Tyr (2)^a.