Table IV. Rates of mortality, CHF, and cardiac impairment comparing rapid and nonrapid progressors in HIV-infected children.
Cohort of children known to be HIV-infected at enrollment (group I) | |||||
---|---|---|---|---|---|
| |||||
Event | Rapid progressors (n = 71) | Nonrapid progressors (n = 134) | P value | ||
|
|
||||
Rate/100 child-years | 95% CI | Rate/100 child-years | 95% CI | ||
Death | 12.9 | 9.1, 18.2 | 6.1 | 4.4, 8.5 | .004 |
CHF | 5.7 | 2.9, 10.3 | 2.1 | 1.0, 3.9 | .04 |
Cardiac impairment | 16.2 | 11.1, 23.5 | 7.6 | 5.4, 10.7 | .007 |
Repeat cardiac impairment | 50.9 | 41.5, 62.4 | 29.6 | 25.0, 35.2 | <.001 |
Neonatal cohort (group II) | |||||
| |||||
Rapid progressors (n = 45) | Nonrapid progressors (n = 48) | ||||
|
|
||||
Event | Rate/100 child-years | 95% CI | Rate/100 child-years | 95% CI | P value |
| |||||
Death | 18.9 | 12.7, 28.1 | 2.1 | 0.6, 5.3 | <.001 |
CHF | 2.8 | 0.6, 8.2 | 0.6 | 0.0, 3.6 | .37 |
Cardiac impairment | 9.5 | 4.4, 18.0 | 2.0 | 0.4, 5.7 | .02 |
Repeat cardiac impairment | 27.1 | 18.6, 39.4 | 3.3 | 1.1, 7.6 | <.001 |