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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Inflamm Bowel Dis. 2015 Jan;21(1):1–7. doi: 10.1097/MIB.0000000000000268

TABLE 1. Summary of Results for 6 SNPs Associated with CD in Koreans.

No. Samples RAF
SNP Risk Allele Chromosome Location Gene(s) or Locus Study Case Control Case Control Pa OR 95% CI P-BDb
rs3749172 A Chr2: 241,570,249 GPR35 Immunochip 722 461 0.36 0.28 5.57 × 10−5 1.44 1.20–1.72
Replication 894 967 0.35 0.27 7.31 × 10−8 1.50 1.29–1.74
Combinedc 1616 1428 0.36 0.28 5.30 × 10−11 1.45 1.29–1.61 0.912
rs224143 G Chr10: 64,477,836 (ZNF365) Immunochip 722 461 0.67 0.60 3.31 × 10−4d 1.36 1.15–1.60
Replication 938 966 0.66 0.59 3.24 × 10−6 1.37 1.20–1.56
Combinedc 1660 1427 0.67 0.59 2.20 × 10−9 1.38 1.24–1.53 0.922
rs1250569 T Chr10: 81,045,207 ZMIZI Immunochip 722 461 0.57 0.47 1.41 × 10−6 1.51 1.28–1.79
Replication 945 975 0.53 0.48 6.45 × 10−3 1.19 1.05–1.35
Combinedc 1667 1436 0.55 0.48 3.05 × 10−7 1.30 1.18–1.44 0.030
rs4409764 T Chr10: 101,284,237 (NKX2-3) Immunochip 722 461 0.51 0.46 1.18 × 10−2d 1.24 1.05–1.47
Replication 932 955 0.53 0.45 7.40 × 10−7 1.39 1.22–1.59
Combinedc 1654 1416 0.52 0.46 7.93 × 10−8 1.32 1.19–1.46 0.308
rs514000 C Chr18: 12,854,072 PTPN2 Immunochip 722 461 0.39 0.30 4.94 × 10−5 1.43 1.20–1.70
Replication 941 974 0.40 0.34 4.13 × 10−4 1.27 1.11–1.44
Combinedc 1663 1435 0.39 0.33 9.00 × 10−8 1.33 1.20–1.48 0.238
rs2823256 G Chr21: 16,784,706 (NRIP1, USP25) Immunochip 722 461 0.75 0.69 7.01 × 10−4e 1.38 1.14–1.66
Replication 939 968 0.76 0.70 6.45 × 10−5 1.35 1.16–1.56
Combinedc 1661 1429 0.76 0.70 2.49 × 10−7 1.35 1.20–1.51 0.814

CI, confidence interval; OR, odds ratio; RAF, risk allele frequency.

a

P value obtained from Cochrane–Armitage trend test.

b

P BD: asymptotic P value of the Breslow–Day (BD) test for heterogeneity of the odds ratio.

c

Combined: combined P value (PCMH) and combined OR were calculated by Cochran–Mantel–Haenszel (CMH) test statistic (1 df).

d

These SNPs were selected as reported SNPs in Caucasian GWAS studies.

e

This SNP was selected as the proxy of rs200642633 (insertion/deletion SNP) (r2 = 0.91, D′ = 0.96).