Table 4.
Estimated sample size (completers) required to detect 25% treatment effect with 80% power and alpha=0.05
| Composite measure* | Month | Total n | Adjusted MSDR | Estimated sample size (completers)/group |
|---|---|---|---|---|
| Unweighted | 60 | 56 | 1.62 | 97 |
| Unweighted | 24 | 95 | 1.06 | 225 |
| Weighted | 60 | 56 | 1.93 | 69 |
| Weighted | 24 | 95 | 1.19 | 179 |
*
Composite measure includes: CERAD Word List Recall, CERAD Boston Naming Test-High, MMSE Orientation to Time, Constructional Praxis, and Raven’s Progressive Matrices
CERAD = Consortium to establish a Registry for Alzheimer’s Disease
MMSE = Minimental State Exam