Table 5.

Estimated minimal detectable treatment effect required using with 75 completers per group, 80% power and alpha=0.05

Composite measure*	Month	Total n	Adjusted MSDR	Detectable treatment effect
Unweighted	60	56	1.62	29
Unweighted	24	95	1.06	44
Weighted	60	56	1.93	24
Weighted	24	95	1.19	39

^*Composite measure includes: CERAD Word List Recall, CERAD Boston Naming Test-High, MMSE Orientation to Time, Constructional Praxis, and Raven’s Progressive Matrices

CERAD = Consortium to establish a Registry for Alzheimer’s Disease

MMSE = Minimental State Exam