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. Author manuscript; available in PMC: 2015 Feb 17.
Published in final edited form as: Free Radic Biol Med. 2009 Jun 12;47(6):750–759. doi: 10.1016/j.freeradbiomed.2009.06.010

Figure 2. Mitochondria-targeted hOggl blocks oxidant-induced A549 cell mitochondrial dysfunction and apoptosis.

Figure 2

(A) Mt-hOgg-1 overexpression prevents amosite asbestos-induced ΔΨm as assessed using a tetramethylrhodamine ethyl ester (TMRE) fluorometric technique. (B): Mt-hOggl overexpression abolishes asbestos-induced caspase-9 activation and DNA nucleosomal fragmentation.(C): Mt-hOggl overexpression blocks H2O2-induced ΔΨm (TMRE fluorescence) and DNA fragmentation. * p < .05 v. no asbestos or H2O2; † p < .05 v. empty vector cells exposed to the same dose of asbestos or H2O2.