Skip to main content
. Author manuscript; available in PMC: 2015 Feb 17.
Published in final edited form as: Free Radic Biol Med. 2009 Jun 12;47(6):750–759. doi: 10.1016/j.freeradbiomed.2009.06.010

Figure 7. Mitochondria-targeted aconitase overexpression prevents oxidant-induced A549 cell DNA fragmentation and caspase-9 activation.

Figure 7

(A) Mitochondria-targeted aconitase augments aconitase protein levels as assessed by Western blotting and (B) mitochondrial aconitase activity (n=3). (C) Mitochondria-targeted aconitase overexpression blocks oxidative stress-induced DNA fragmentation and caspase-9 activation caused by H2O2 (100 µM) or asbestos (25 µg/cm2) for 24h. * p < .05 v. no H2O2 or asbestos; † p < .05 v. empty vector cells exposed to the same dose of H2O2 or asbestos.